Also, novel PRLR antagonists [18] can be utilized to determine whether they effectively counteract any cutaneous effects of PRL, for example on keratinocyte proliferation [72] and angiogenesis [73].Moreover, laser-capture microdissection may allow the identification of compartment specific PRL gene expression in the skin, although given that the skin and HF contain immune cells, it may be difficult to determine the contribution they play to intracutaneous PRL production. This evidence concerns the gene PRLR and hydrops fetalis.