In humans, genes encoding for the α1 and α2 chain of type VI collagen (COL6A1 and COL6A2 respectively) are located on the long arm of Hsa21, 21q22.3, a region determined to be critical for CHD associated with trisomy 21 (Francomano et al., 1991). This evidence concerns the gene COL6A2 and coronary artery disorder.