IFNB1 and myeloid sarcoma: T cell recruitment into the CNS may require Type I IFN to induce relevant CXCR3 attracting chemokines, however other studies have also showed that prolonged IFN-β treatment in MS patients down-regulates the expression of cell adhesion molecules such as VCAM-1 and ICAM-1 in brain endothelial cells, resulting in reduced immune cell infiltration into the CNS (Corsini et al., 1997; Defazio et al., 2000).