On the other hand, 5-HT1A agonists display anxiolytic/antidepressant activity in animal models (Martin et al., 1990; De Vry, 1995; Carr and Lucki, 2011) whereas 5-HT1A receptor antagonists reverse drug-induced cognitive deficits (Harder and Ridley, 2000; Mello e Souza et al., 2001; Misane and Ögren, 2003). This evidence concerns the gene HTR1A and Cognitive impairment.