MPST and neuropathy: In addition, the decline in TST and MPST activities (which under physiological conditions are about 5–10 times lower in the brain than in other organs, like the kidney or heart) can increase sensitivity of the brain structures (especially striatum and SN) to the CN− toxicity, leading to the inhibition of cytochrome oxidase, and thus to the decrease in ATP level and neuropathy (de Sousa et al. 2007; Hasuike et al. 2004; Nagahara et al. 1999).