This study was supported by American Cancer Society Grant “The interplay between prostate-specific antigen and galectin-3 during prostate cancer progression” IRG 11-053-01-IRG (to V. B.), and partially supported by a National Institutes of Health grant R37CA46120-19 (to A. R.), and by NIH Cancer Center Support Grant CA-22453. The gene discussed is KLK3; the disease is Familial prostate cancer.