PORCN and neoplasm: Among the overexpressed mRNAs were: porcupine (PORCN), encoding an O-acyltransferase responsible for lipid-modifying Wnt ligands prior to secretion [42]; FZD2, encoding a Wnt/Ca2+ signaling-related Frizzled receptor [43]; and MYC. Repressed genes included those coding for Wnt antagonists such as WIF1 (discussed above) and PRICKLE1, a putative tumor suppressor that represses the Wnt pathway by destabilizing Dvl [44].