Rivaroxaban showed an increased incidence of haematuria and epistaxis in ROCKET AF (Rivaroxaban Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) (18), and in RE−LY (Randomized Evaluation of Long-term anticoagulation therapY) dabigatran showed higher rates of dyspepsia (17) compared with warfarin. The gene discussed is F10; the disease is atrial fibrillation.