It is also recognized that maladaptive production of various adipocytokines (e.g. adiponectin, resistin, visfatin, and leptin) and pro-inflammatory cytokines, such as tumor necrosis factor-α (TNFα) and interleukin (IL)-6, are implicated in the development of obesity-related systemic inflammation and insulin resistance. The gene discussed is TNF; the disease is Insulin resistance.