High AEA levels in the duodenal mucosa of untreated celiac disease (UCD) patients in comparison to treated celiac disease (TCD) patients and control subjects (CS) [11] are likely due to an altered N-acylphosphatidyl-ethanolamine specific phospholipase D (NAPE-PLD) activity [12], and might self-induce an increase of CBR, as a fine mechanism of regulation common to many diseases [11], [13], [14]. The gene discussed is GPLD1; the disease is celiac disease.