Seminal vesicles from TRAMP-CAST (n = 15), TRAMP-PWK (n = 37), TRAMP-WSB (n = 68) and TRAMP-A (n = 65) showed significantly less tumor growth (age adjusted seminal vesicle burden = 0.20±0.03 g, 0.31±0.02 g, 0.57±0.04 g and 1.08±0.08 g respectively; P<0.020) compared to wildtype C57BL/6J-Tg(TRAMP)824Ng/J males (seminal vesicle burden = 1.36±0.10 g, n = 39; Fig. 1c). Here, CAST is linked to neoplasm.