Compared to wildtype C57BL/6J-Tg(TRAMP)824Ng/J males, tumor associated mortality was significantly higher in TRAMP-NOD (hazard ratio [HR] = 2.26 [1.76–2.92]; P<0.001), TRAMP-CAST (HR = 3.03 [1.77–5.16]; P<0.001) and TRAMP-NZO (HR = 1.18 [1.02–1.35]; P = 0.022). The gene discussed is CAST; the disease is neoplasm.