Nan Bi et al. examined five functional COX-2 polymorphisms and suggested that only COX-2 rs689466 polymorphism was a potential predictive marker for survival in locally advanced NSCLC patients treated with chemoradiotherapy or radiotherapy alone and the GA and GG genotypes were significantly correlated with better overall survival and with longer progress-free survival compared with the rs689466 AA genotype [20]. The gene discussed is PTGS2; the disease is non-small cell lung carcinoma.