PTGS2 and carcinoma of esophagus: COX-2 overexpression shows reduced apoptotic susceptibility by up-regulation of Bcl-2 and suppression of CASP3 and CASP9, two important families of apoptosis-related molecules [10]–[11].It is reported that COX-2 is overexpressed in various malignancies such as gastric carcinoma, esophagus carcinoma, including NSCLC, suggesting its involvement in pulmonary tumorigenesis [12]–[14].