Although these clinical features appear to be due to an enlarged tectum and only demonstrate partial clinical similarity with CMI, Miro and colleagues suggest that an additional link between SUZ12 and central nervous system disorders may come from neurofibromatosis 1 (NF1), a disorder characterized by the development of neurofibromas and the presence of café-au-lait spots [79]. This evidence concerns the gene NF1 and Cafe-au-lait spot.