PCLO and major depressive disorder: During correct recognition>correct rejection (in the recognition phase) of positive words we found a significant interaction of emotion × diagnosis × genotype: During rejection of positive new words, healthy PCLO− carriers showed increased left amygdalar activation, while no difference between processing positive old and new words was observed in PCLO+ carriers and in MDD patients, indicating blunting to novel positive information in PCLO+ carriers and patients (MNI [−27 −3 −24]; Z = 3.36; Figure S5 in File S1).