From the list of down-regulated synaptic density genes, we have further analyzed the expression of respective proteins which plays an important role in the maintenance of dendritic architecture and spine density i.e activity regulated cytoskeleton protein (ARC), Glutamate receptor 1 (GRIN1)/N-methyl-D-aspartate receptors subunit 1 (NMDAR1) and Glutamate receptor metabotropic 1 (GRM1) in both clade B and clade C infected astrocytes and SK-N-MC neuroblastoma cells. Here, GRM1 is linked to neuroblastoma.