PCK2 and hepatocellular carcinoma: Indeed, both genes are bound by C/EBPβ and this has been shown for 11β-HSD1 in several cell types (Arai et al. 2007, Sai et al. 2008, Yang et al. 2009), including adipocytes (Esteves et al. 2012), and for PEPCK in hepatoma cells (Park et al. 1993, Choudhury et al. 2011).