Deletion of the highly evolutionarily conserved creb gene alone or in combination with the related family member, crem, has shown the need for these TFs in developing and adult brain and in T-cell recovery in irradiated mice.7, 8, 9 In addition, in vitro and in vivo studies show that CREB also has a role in oncogenesis influencing melanoma, T-cell and myeloid leukemia, hepatocellular carcinoma, clear cell sarcoma, lung adenocarcinoma,10 as well as CRC.11 The gene discussed is CREB1; the disease is clear cell sarcoma.