The pattern of DR6 IR in the hippocampus of AD patients (Braak stage V-VI) was similar to that observed in DS with AD pathology (Additional file3: Figure S3), with strong DR6 IR in dystrophic neurites in and around amyloid plaques (Additional file3: Figure S3 B-D) and colocalization with APP and hyperphosphorylated Tau (Additional file3: Figure S3 E-H). This evidence concerns the gene MAPT and Alzheimer disease.