AFP and hepatocellular carcinoma: The median of AFP and PIVKA-II in HCC patients with malignant portal vein invasion was 813.2 ng/mL (range, 1.8–200,000 ng/mL) and 482.0 mAU/mL (range, 12–1,200 mAU/mL), respectively, but the median in HCC patients without portal vein invasion was 26.4 ng/mL (range, 1.0–2,121,720 ng/mL) and 42.0 mAU/mL (range, 2–2,000 mAU/mL), respectively (P <0.001 and P <0.001, respectively).