We among others have undertaken a program of work which has investigated the role of TNF-α in the pathogenesis of uveitis[26], leading to the development of an anti-TNF-α fusion protein (TNFr-Ig) in 1996 which we evaluated first in an animal model of uveitis[27,28], and subsequently in a Phase II/proof of concept clinical trial in 2004[4,29]. Here, TNF is linked to uveitis.