TCF7L2 and type 2 diabetes mellitus: We have identified a significant elevation of TCF7L2 mRNA in pancreas,especially among the CCCA insertion carriers, which appears to increase diabetesrisk by increasing the expression of TCF7L2 among ‘T’ risk allelecarriers of rs7903146 of TCF7L2. These results suggest a synergistic effectof Wnt16a insertion and the at-risk ‘T ’allele ofTCF7L2 in compounding the risk of T2D, likely through elevatedβ-cat/TCF7L2 activity and the expression of downstream Wnt targets.