TNF and obesity due to melanocortin 4 receptor deficiency: The prevalence of the CCCA insertion polymorphism did not differsignificantly among diabetic cases (33%) versus controls (32%) in our cohort.Although our epidemiological data did not clarify the role of CCCA insertion in T2D,obesity, or lipid metabolism (Table 1), our multiple linear regression resultsshowed significant elevation in serum TNFα levels among insertion carriersversus non-carriers (p= 0.008), as well as a non-significant trend in the samedirection for another inflammatory marker, MCP-1 (p=0.44).