Subsequently, it was shown that the defective tumor immunity observed in Jα18-/- mice, selectively deficient for iNKT cells, against methylcholanthrene-induced sarcomas and melanoma lung metastasis could be restored by adoptive transfer of IFN-γ-producing iNKT cells from WT donor mice (Crowe et al., 2005). This evidence concerns the gene IFNG and neoplasm.