High frequencies of circulating CD8+ T lymphocytes were detected in patients with metastatic melanoma, specific for Melan-A/MART-1, MAGE-10, and Ny-Eso-1, and CTL have also been found infiltrating melanoma metastases (Clark et al., 1989; Clemente et al., 1996; van Houdt et al., 2008; Fuertes et al., 2011). Here, MLANA is linked to metastatic melanoma.