These cells are conserved between humans and mice and are implicated in many immunological processes, such as production of massive amounts of several cytokines, both pro-inflammatory (i.e., IL-2, IL-17, IFN-γ, and TNF-α) and regulatory (i.e., IL-4, IL-10, and IL-13), which reflect their capacity to differently regulate anti-tumor responses (Swann et al., 2004; Bendelac et al., 2007; Exley et al., 2011). The gene discussed is IFNG; the disease is neoplasm.