Quantitatively, in the middle of the tumor we found a clear statistical relationship between expression of Ki-67 and the lack connexin expression (Chi-square test: Cx43: p < 0.0001; Cx45: p < 0.03, Cx40: p < 0.014) where those cells expressing Ki-67 co-expressed significantly more rarely connexin (Figure 6A). Here, GJA5 is linked to neoplasm.