It remains to be determined how changes in editing of endogenous Nova1 impact on the splicing of its targets, and whether or not aberrant Nova1 editing could aggravate motor neuron demise in sporadic amyotrophic lateral sclerosis (ALS); a condition strongly associated with deficient ADAR2 expression and GluA2 Q/R site editing (e.g., Hideyama et al., 2010, 2012). Here, GRIA2 is linked to amyotrophic lateral sclerosis.