MRC1 and hereditary elliptocytosis: Under these conditions, sTIE2-mediated ANG blockade prevented macrophage skewing towards the M2-like (MRC1+) phenotype in ligated WT → WT mice and both ligated and non-ligated HE → WT mice (Fig 2A), whereas it did not affect the total number of infiltrating F4/80+ macrophages in either genotype (Fig 2B).