Kinetic analyses of four ITD+ AML patients who entered CR but then relapsed between 16 and 24 months after FD showed a consistent pattern of arrested terminal differentiation of myeloid DCs and upregulation of IL-10 (an anti-inflammatory cytokine), TNF-α, IL-6, and IL-1β (pro-inflammatory cytokines) months prior to leukemia relapse. The gene discussed is TNF; the disease is acute myeloid leukemia.