In this study, we show that the high frequency of precursor DCs in 16 FD ITD+ AML samples (Lin−/HLA-DR+/CD11c+/CD123+) was associated with a lack of terminal DCs (myeloid DCs: BDCA-1+ or BDCA-3+; plasmacytoid DC: BDCA-2+). The gene discussed is CLEC4C; the disease is acute myeloid leukemia.