Similarly, the association between ICAM1 polymorphisms seizures with severe malaria (Kun et al., 1999) could be explained by the binding of ICAM1 to P. falciparum–infected erythrocytes onto brain microvasculature (Berendt et al., 1992; Kun et al., 1999) causing sequestration. Here, ICAM1 is linked to malaria.