A similar result was observed in the serum of c-fms-rtTA/(tetO)7-CMV-MMP12 spontaneous lung tumor mouse model with tumor (Figure 4, lower left panel), in which the average CHI3L1 concentration was more than 6 times higher in tumor mice than that of doxycycline-untreated control mice. This evidence concerns the gene CHI3L1 and neoplasm.