MMP12 and neoplasm: The study was also repeated in two systemic inflammation-induced tumor models (Figure 4), in which MMP12 and Api6 were overexpressed in myeloid cells of c-fms-rtTA/(TetO)7-CMV-MMP12 and c-fms-rtTA/(TetO)7-CMV-Api6 bitransgenic mice [2], [4].