To that end, a number of recent studies including studies from our group have shown that the inhibition of constitutive NFκB activation, one of the frequent molecular alterations in PC [30], [31], inhibits tumorigenesis [31]–[33], progression [34]–[36] and metastasis [19], [37], [38]. This evidence concerns the gene NFKB1 and pachyonychia congenita.