Thus, given that tolcapone increased ventral hippocampal dopamine, relative to vehicle, our data are arguably more directly relevant to reported links between COMT and anxiety, than those with memory (although, as outlined in the following section, a lack of an effect of COMT inhibition on tissue dorsal hippocampal dopamine does not exclude the possibility of functional effects of COMT in this region). The gene discussed is COMT; the disease is Anxiety.