NFKB1 and gastric cancer: In the present study, we developed a dual imaging reporter system to investigate the differential expression of miRNA-16 response to various anticancer drugs both in vitro and in vivo, and found that two clinical drugs, VP-16 and 5-FU, can upregulate miRNA-16 expression in a p38 MAPK-dependent but NF-κB-independent manner in gastric cancers.