In order to investigate whether this up-regulation of GRP78 in myofibroblasts induced by lung cancer NCI-H460 cells is only limited to one type of the cells, we co-cultured another type of lung cancer cell line SPCA-1 (The Cell Bank of Type Culture Collection, Shanghai, China) and fibroblast cell line HFL1 on this device as well. This evidence concerns the gene HSPA5 and lung cancer.