CENPB and systemic sclerosis: If successful, this approach should provide more specific predictive and prognostic clinical information than is currently possible through the detection of anti-CENP-A and –CENP-B Abs using the whole recombinant proteins in ELISA or LIA, which appeared only to slightly increase the diagnostic sensitivity for SSc compared to the detection of anti-CENP-B only [12], [26].