Both ALT and GGT are inflammatory markers; AAR and albumin are associated with liver fibrosis; AFP is associated with liver cell proliferation; and decreased alpha-1 globulin proteins may either be a sign of alpha-1 antitrypsin deficiency related to the pathogenesis of HCC, or reflect the reduced production of required proteins due to impaired liver function. The gene discussed is GPT; the disease is hepatocellular carcinoma.