This set of predictors has been previously reported to have good validity in predicting the 3-, 5- and 10-year risk of HCC in patients with chronic hepatitis B. [14] Risk Model II included age, gender, and the liver-related seromarkers ALT, AAR, AFP, GGT, albumin, and alpha-1 globulin as predictors, but did not include HBV seromarkers. The gene discussed is ALB; the disease is chronic hepatitis B virus infection.