GPT and Cirrhosis: A number of risk predictors for HBV-associated HCC have been identified in previous studies.[4]–[10] They include older age, male gender, family history of HCC, elevated serum level of alanine aminotransferase (ALT), alcohol drinking, cirrhosis status, hepatitis B e antigen (HBeAg) seropositivity, high HBV DNA viral load, HBV genotype C, and the HBV core promoter mutation.