Notably, six of the VUS (Q1409L, S1473P, E1586G, Y1703S, W1718L and G1770V) had not been recorded in the locus-specific database for mutations in BRCA1 and BRCA2, BIC (Breast Cancer Information Core database, http://research.nhgri.nih.gov/bic/) (Figure 1 and Table 1). Here, BRCA1 is linked to medical procedure.