Two clinical studies reported increased levels of plasma peroxides and methemoglobin (MetHb) as oxidative stress markers in patients with CFS [20], [45].Therefore, we examined the serum levels of biomakers associated with oxidative stress and antioxidant-associated biomarker profiles before and after 4 weeks of P. ginseng administration. Here, HBG2 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.