APOA1 and cardiovascular disorder: Plasma HDL-cholesterol (HDL-c) levels are known to be inversely correlated with the risk of atherosclerotic cardiovascular diseases [1], however, this inverse relationship between HDL and cardiovascular disease reported in epidemiological studies is not confirmed in subgroups of patients with specific apoA-I mutations as ApoA1 Milano [2] or CETP polymorphism [3].