Hyperglycemia creates a proinflammatory microenvironment, and inflammatory processes and biomarkers of inflammation contribute to PN [28].In addition, deficits in neurotrophic factors such as nerve growth factor and changes in the secretion of neuroeffector peptides such as substance P and calcitonin gene-related peptide can be responsible for neuropathy. The gene discussed is TAC1; the disease is neuropathy.