Moreover, tumor-infiltrating lymphocyte (TIL) density seems to have a better prognosis value than TNM stage [3], and some T cell subpopulations have been shown to be associated with a better CRC clinical outcome, such as cytotoxic T cells (CD8+), Th17 helper T cells and, more controversially, regulatory T cells (FoxP3+) [3]–[5]. This evidence concerns the gene FOXP3 and neoplasm.