A significantly higher total T cell density was observed in tumor as compared to normal colon tissues (p<0.05, data not shown), as already reported.13 Within the tumor and normal tissues, CD3+, CD8+ and FoxP3+ TIL densities were higher in the stroma than in the epithelium (p<0.01 for all markers) (Figure 2). The gene discussed is FOXP3; the disease is neoplasm.