The finding that the number of CCT/TRiC and prefoldin particles within the cytosol of cancer cell lines do not differ by over one order of magnitude indicate either that the folding machinery has evolved in such a way that prefoldin and/or Hsc/p70 function in conjunction with CCT or that the maximum amount of client polypeptides the folding machinery can store/buffer and the cell can accommodate is of the same order of magnitude than that of CCT/TRiC particles. Here, MARVELD2 is linked to cancer.