Bassullu et al. have investigated the predictive and prognostic significance of c-erb-B2, EGFR, PTEN, mTOR, PI3K, p27, and ERCC1 expression in HCC in the Hepatitis Monthly HCC special issue (45), and concluded that deregulation of those pathways may serve as a prognostic marker for tumor aggressiveness. The gene discussed is MTOR; the disease is hepatocellular carcinoma.