In addition, in response to long‐term pressure overload, cardiomyocyte apoptosis may further contribute to the transition from LV hypertrophy to heart failure.32 By Western blot analysis, we quantified the protein expression of the antiapoptotic gene, Bcl‐2, and the proapoptotic gene, Bax, which are involved in the apoptotic pathway (Figure 7A). Here, BAX is linked to heart failure.