However, to date, no major susceptibility gene such as BRCA1 for breast cancer, has been identified for NPC with significantly increased risk, although several genes including HLA haplotypes (12) and genes of T cell receptors (13), cytochrome P450 2E1 (14), TLR family (15,16), DNA repair enzymes XRCC1 and hOGG1 (17), have been reported to be associated with the risk of NPC. Here, LIG4 is linked to nasopharyngeal carcinoma.