The release of cytokines, especially TNF-α, IL-1β, IL-6, IL-12 and IFN-γ, and the generation of free radicals by PMNs and infiltrated macrophages in the tissues can lead to microvascular dysfunction and organ failure [186]; TNF-α and NO are essential mediators in the pathogenesis of sepsis and associated complications [187]. Here, TNF is linked to Sepsis.