SPP1 and coronary artery calcification: In multivariate Cox regression analysis, the results showed that serum uric acid (odds ratio (OR) = 1.42, 95% CI = 1.20–1.82, and P < 0.001), osteopontin (OR = 1.14, 95% CI = 1.12–1.25, and P < 0.001), osteoprotegerin (OR = 1.45, 95% CI = 1.20–1.89, and P < 0.001), type two diabetes mellitus (OR = 1.41, 95% CI = 1.20–1.72, and P < 0.001), and total cholesterol (OR = 1.13, 95% CI = 1.10–1.22, and P < 0.001) were factors that independently associated with coronary artery calcification (Figure 1).