ERBB2 and breast cancer: They demonstrated that breast cancer patients with CAM had significantly worse histopathological features, such as higher tumor grade (81% grade 3 carcinomas), lymphovascular invasion (LVI) (81%) larger primary breast tumours (95% cT3/cT4 breast carcinoma), ER-receptor negativity (52%), and HER-2 overexpression (42%) [3].