Furthermore, GutGard exhibited anti-inflammatory activity likely through inhibition of COX and LOX pathways [28] and anti-ulcer activity was demonstrated in pylorus ligation, cold-restraint stress, and indomethacin induced ulcer in albino Wistar rats in which at 12.5, 25, and 50 mg/kg dose levels, the effects were found in dose dependent manner [30]. This evidence concerns the gene LOX and ulcer disease.