Interestingly, the expression of MMP-9, B7H1, and ARG1 was observed at the same areas as the CD163+ macrophage-infiltrating areas of invasive EMPD (Figures 3(d), 3(f), and 3(h)), whereas few MMP-9, B7H1, and ARG1 expressing cells were detected in noninvasive EMPD (Figures 3(c), 3(e), and 3(g)). Here, CD274 is linked to extramammary Paget disease.