One of the possible explanations for the additional antitumor effects of BPs is that pharmacological inhibition of MMP9 by aminobisphosphonate decreases pro-MMP9 and VEGF in the serum and abrogates the suppressive function of immunosuppressive cells and induces the antitumor immune response both locally and at sites remote from the tumor [6]. The gene discussed is MMP9; the disease is neoplasm.