Interestingly, only invasive EMPD possessed substantial numbers of CD163+ M2 macrophages and MMP-9+ cells, B7H1+ cells, and ARG1+ cells around the tumor, whereas few CD163+ M2 macrophages, MMP-9+ cells, B7H1+ cells, and ARG1+ cells were observed in noninvasive EMPD. This evidence concerns the gene CD163 and extramammary Paget disease.