ESM1 and neoplasm: Interestingly, the tumor cell lines release in vitro Endocan as a DSPG [36, 84] and the secretion of Endocan by these tumor cells was shown to be upon regulation of proinflammatory molecules such as TNF-α and of proangiogenic growth factors such as FGF-2 as previously described for endothelial cultured cells [24].