In this context, it is of importance that in ASMC-derived from patients with severe asthma the binding of Nrf2 to the antioxidant response elements as well as the expression of HO-1 was reduced when compared to ASMC of nonasthmatic controls [110] suggesting that activation of Nrf2 and upregulation of HO-1 by DMF may compensate this pathology. This evidence concerns the gene HMOX1 and asthma.